Over 50% of the population has an MTHFR genetic mutation, which can slow down methylation and lead to elevated homocysteine levels. High homocysteine has been linked to cardiovascular risks, as it can damage artery linings and promote excessive blood clotting. It is also associated with cognitive issues, as proper neurotransmitter metabolism relies on optimal methylation. Many believe that simply taking B vitamins is enough, but most B vitamins on the market are non-methylated, making them ineffective for individuals with high homocysteine levels. This supplement provides bioactive methylation-supporting nutrients for better absorption and effectiveness: Folate (L-5-methylfolate) Vitamin B12 (methylcobalamin & adenosylcobalamin) Vitamin B6 (P-5-P) Vitamin B2 (riboflavin; R-5-P) Betaine (TMG) This targeted formula helps support methylation, balance homocysteine levels, and promote heart and brain health.